Old Trafford is now home to nothing more than an injury crisis and it was only significantly increased by Thursday's clash, with both Marcos Rojo and Zlatan Ibrahimović going off during the win over Anderlecht with seemingly serious knee injuries.
It was later confirmed that the 35-year-old suffered a cruciate knee-ligament damage, and will likely miss the rest of the season.
And the seriousness of the injury could even potentially end the Swede's career, with his advancing years coupled with the fact his contract at Old Trafford is due to expire at the end of the season.
Manchester United want to bring in both Atletico Madrid's Antoine Griezmann and Andrea Belotti of Torino this summer, and have made progress with both mega deals, as they continue to consider their attacking options in the wake of Zlatan Ibrahimovic's injury.
"First of all, thank you for all the support and love", he said in a post on his Instagram page.
After the game, not a lot of players went to social media to speak to their fans, but we did get some reactions from Sergio Agüero, Willy Caballero and coach Pep Guardiola, who also spoke to the media. "I wouldn't accept one guy to play nine matches in a row", he said. "They are a very hard team".
Maoist rebels kill 12 Indian paramilitary soldiers
The CRPF personnel had split into two groups. "Shri Ahir is going to Chhattisgarh to take stock of the situation", he tweeted. In March, 12 officers died in a suspected Maoist attack on another convoy in the same district.
It certainly promises to be a fascinating encounter, with Mourinho choosing to make a string changes for the 2-0 win at Burnley in a bid to freshen up his squad with half an eye on Thursday.
But asked if that was a calculated risk, Mourinho told Sky Sports on Tuesday (April 25): "I don't care". We were thinking about them. It's really sad for them.
Unfortunately they won't be the first or last players to get an important injury.
Jose Mourinho says that Ander Herrera only dubbed Thursday's Manchester derby as "the game of the season" because he is finally "getting my message". If we win we have the chance to finish in the top four, if they win it is going to be very hard. "They have to and when they do it, I'm happy with them, it doesn't matter how they perform".
The Red Devils have already won the EFL Cup this season and have reached the semi-finals of the Europa League, a competition that has a Champions League spot for its winners. "Maybe on Thursday we are going to have a better referee or maybe play without a referee - I'd prefer that".
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