The game kicks off at 1945 BST at the Stade Louis II, live on BT Sport 3.
But lets not forget the unbelievable night in the last round that saw Barca come back from 4-0 down in the first leg to go through.
If former Barcelona defender Dani Alves can keep his friend and compatriot Neymar at bay like he did in the first leg, Juventus should be able to book their place in the semi-finals.
"We have huge respect for Barcelona and we know that we will need to play even better again to go through".
And yet, the oddity of that match was that Barca were far from at their best but still created the better chances and could actually have turned around the 3-0 deficit on the night.
Dybala, in stark contrast, has won just a solitary Serie A, although that total will nearly certainly double this season, and one Coppa Italia after his move to Juventus at the start of last season.
Prior to the Barcelona match last week, the Italians assured the world they have grown psychologically and were confident of their power to compete at the highest level.
The bet I like is Monaco prevailing despite having their backline breached, which was also the case against Spurs and City, and is where I'll be investing.
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Luis Enrique's side was taken apart in the first leg in Turin, losing 3-0 to a Juve team inspired by Paulo Dybala, who scored twice.
The rest of the team is expected to be unchanged from the team that played last week.
Tiemoue Bakayoko will return from suspension for Monaco, but Fabinho will miss the game after being cautioned in Dortmund. Barca had 14 shot attempts in the first leg but only three on target.
Barca scored three times in the final two minutes plus stoppage time as PSG froze in a grandstand finish six weeks ago. In fact, their only defeat on home soil versus a team from Germany was against Borussia Mönchengladbach in the UEFA Cup back in October 1996 (0-1). In the Champions League, there is no time to take your foot off the pedal.
The Barca man had a whopping 87 assists before his 24th birthday compared with Dybala's 33, although the latter can boast the accolade of most assists in Serie A in 2014/15 - something Messi can't say by virtue of him never playing in Italy. It's not as if I know better than them, it's that we all have to unite our experiences and capabilities to give Juventus the dream of winning the Champions League after 21 years. Everyone from Real Madrid to Bayern Munich can testify to that.
- Barcelona have reached the quarter-finals for the 10th consecutive season, the longest run in the history of the Champions League.
Borussia Dortmund have lost eight of their last 11 games in the Champions League knockout stages (W3). In fact, Dortmund's games have produced more goals than any other team (40 - 27 for & 13 against).
"After three years, it is normal to have a bond with this competition", Allegri added. "We'll score the first, the Camp Nou will score the second and the third will come all on its own", he said.
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