C J.T. Realmuto returned to the lineup after battling an illness shortly after delivering a walk-off RBI double on Friday.
Justin Bour and Marcell Ozuna hit consecutive homers for Miami in the second inning.
Kyle Barraclough worked a 1-2-3 seventh for the Marlins, with one of the outs coming when Giancarlo Stanton had to make a long run toward the foul pole before coming down with the ball.
After Rojas touched home plate, the Marlins stormed the field to celebrate.
"We're exhausted here", Collins said. Cespedes led off the fifth with another homer, his sixth of the season - most in the majors - and his fifth in 48 hours. Kyle Barraclough pitched a hitless seventh before turning it over to Brad Ziegler, who gave up Walker's hit.
First, he had a blood blister on the Mets' Opening Day, and now, he tore his fingernails on his index and middle fingers and was forced to exit New York's game Friday against the Marlins earlier than he would have liked.
For the second time in as many days, a manager relieved his starter during a no-hitter with plenty of game left to play. "It's still April, there's a lot that can happen". When I needed to ramp up and throw a little bit harder, I was able to do that.
"As simple as it sounds, I need to maintain my nails". Despite receiving three quality starts from their three best pitchers, the Mets were unable to record a single victory.
While Syndergaard was struggling with his fingernails, Miami's Edinson Volquez was just exhausted.
"He's not afraid to throw strikes", Collins said. "He was a warrior tonight".
After the Mets stranded Cabrera, Collins turned to Reed for the bottom of the inning with his closer being one of the team's relatively fresh relievers.
F1: I f****d it up, fumes Bahrain GP runner-up Lewis Hamilton
After battling for a points finish, the Spaniard endured the agony of having to retire two laps from the end with engine trouble. Fernando Alonso was the last classified finisher in P14 for McLaren, pitting with three laps to go due to an engine failure.
The Cubs loaded the bases with two outs in the ninth inning before Tony Watson got Ben Zobrist on a grounder for his third save. Gordon then scored on a Christian Yelich sacrifice fly.
NY left fielder Michael Conforto threw out Rojas trying to score from third on a flyout in the seventh.
All ended with one swing of the bat by Mets' catcher Travis D'Arnaud.
The Mets are 4-1 in their last five game threes of a series, and 4-0 in deGrom's last four starts during game three of a series.
Mets starter Robert Gsellman allowed a career-high eight runs in 4 2/3 innings.
Miami almost went up 3-2 in the seventh. The left-hander only allowed one runner to reach second base in his longest outing since August 13, 2014.
CHICAGO - Brett Anderson beat his former team with five solid innings, center fielder Albert Almora Jr. made two outstanding catches against the ivy and Chicago beat Los Angeles. "The ball got to me pretty quickly". I didn't know if it was going to get out. "Yeah, I was sacked up".
"I didn't even see it go out", Riddle said. Ozuna doubled to left-center to score Yelich, but Bour was thrown out at the plate when he missed the bag. Miami sent RHP Nick Wittgren to Triple-A New Orleans. Given the Marlins' exhausted bullpen, they needed someone who was fresh. The Mets recalled left-hander Sean Gilmartin from Triple-A Las Vegas and optioned infielder T.J. Rivera to Las Vegas. Due to their recent workload, Mets relievers Addison Reed, Hansel Robles and Josh Smoker were unavailable on Friday. NY is also 4-1 in deGrom's last five Saturday starts, and 1-4 in deGrom's last five starts overall.
The Marlins won the final three of a four-game series.
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