"They say still that it is not very safe, but they can not put forward convincing arguments", Russia's top diplomat said.
The Syrian government claimed on Thursday that USA claims of its culpability for the incident were "100 per cent fabrication".
The incident in the village of Khan Sheikhoun has been condemned by the global community, with the U.S. striking a Syrian airbase with missiles in retaliation.
Moscow has warned against putting the blame on Damascus until an independent inquiry is conducted and vetoed a proposed United Nations resolution on the attack, saying it failed to mention the need to inspect the affected area.
"Our firepower, our ability to attack the terrorists hasn't been affected by this strike", he said.
The Britain-based Syrian Observatory for Human Rights says government troops and allied forces have already entered Madaya, one of the opposition-held towns evacuated of rebels.
But Assad said it was possible to fake video and suggested the whole incident had been staged.
The U.S. launched a surprise missile strike on an airfield in Syria on April 7, the first direct military action Washington has taken against Syrian government forces since the crisis broke out in 2011. The diplomats will discuss the latest developments in Syria, the unilateral attack of USA on Syrian government, and the political solution of the six-year-old crisis in the Arab country. For example, U.K. Prime Minister Theresa May says "apart from anything else, we believe it's the only regime that has the capability to make such an attack".
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Assad said more U.S. attacks "could happen anytime, anywhere, not only in Syria".
The Russian minister added that Moscow doubts the objectivity of the current mechanisms for investigating alleged use of chemical weapons in Syria, considering the difference in how the Organization for the Prohibition of Chemical Weapons (OPCW) handles reports by Damascus and by other parties.
Russian Federation said the gas was part of rebel stockpiles, which the rebels have denied.
Russian Foreign Minister Sergey Lavrov (C) and Iranian Foreign Minister Mohammad Javad Zarif attend a joint press conference in Moscow, Russia, on April 14, 2017.
Mr Lavrov said Russia, Iran and Syria have demanded a "thorough, objective and unbiased investigation" under the auspices of the OPCW, insisting it must use "independent experts", including from Moscow.
Hours after the military operation, Prime Minister Benjamin Netanyahu expressed his support for the U.S. air strike, calling the use of chemical weapons "unacceptable".
It was the first direct United States military action against Assad's forces since the start of Syria's civil war six years ago and led to a quick downward spiral in ties between Washington and Moscow.
Assad has consistently denied using chemical weapons at any point during Syria's six year civil war.
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