Fully rested after the worldwide break and a yellow-card suspension, Messi returns to Barcelona's team for the decisive Spanish league match against Sevilla on Wednesday.
Barcelona are now two points behind Real Madrid in the La Liga table, with the leaders possessing a game in hand.
The La Liga match between Barcelona and Sevilla will be broadcast live on BeIN Sports.
Tuesday marked bearded Messi's 50th official game, and he celebrated the occasion in style with two goals to down Sevilla in a 3-0 victory at Camp Nou.
The Catalan giants remain two points behind Real Madrid, who also won on Wednesday, a nd their ruthless display left their outgoing manager Enrique thrilled.
However, since then Sevilla have been knocked out of the Champions League by Leicester City and tumbled out of contention for the La Liga title with Atletico Madrid passing them into third place.
MADRID (AP) Lionel Messi is back, and just in time.
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I've concluded that based upon hundreds of tales of woe, of mistreatment, by United , is that, here's what we want as a society. Mrs Bell told CNN that United reached out to her husband on Thursday to apologise and to offer compensation for the incident.
His celebration saw him head off towards one of the pitchside cameras at Camp Nou, where he swiped two fingers across his cheek. Add in a big question mark for the health of Stevan Jovetic, and Sevilla may just not have the firepower they need to get the job done.
Suarez made no such mistake as he caught Messi s deflected cross flush with an overhead kick to break the deadlock with his 31st goal of the season. "Being a striker you always know where the goal is and where the ball is to be able to find the net", the Uruguayan told reporters after the game.
Messi has often been the subject of criticism for Argentina's failures and the 29-year-old came in for more scrutiny after receiving a four-match ban for verbally abusing an assistant referee during a 1-0 World Cup qualifying win over Chile last month.
Sevilla was fighting for the league title not long ago, but is now enduring its worst moment of the season.
Luis Enrique announced earlier this week that he'll be taking a year's holiday when he leaves Catalonia at the end of the season.
Luis Enrique's side coasted through the second period to record a ninth win in 10 La Liga matches while the visitors had Vitolo sent off in stoppage time.
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