Police gave chase and the assailants were shot dead at the compound.
The US and the West have said settlement construction and expansion are hindering future plans for a viable Palestinian state.
Video from the Temple Mount esplanade showed Israeli security forces taking cover amid a hail of gunfire, and police shooting a man at close range.
The attack happened shortly after 7 a.m. near Lions' Gate in Jerusalem's Old City, according to NPR. They largely identify with the Palestinian cause. It is the holiest site to Jews and the third holiest in Islam.
Israeli police said they had no comment.
Israel said the killers emerged from the Temple Mount compound with automatic weapons, in what Public Security Minister Gilad Erdan called a "defiling" of the holy site.
Israeli police detained the senior Muslim cleric of Jerusalem after an attack in the city that left two Israeli police officers dead, a son of the mufti of Jerusalem said.
Al-Haram Al-Sharif has been administered by Jordanian Islamic Waqf Ministry since 1948, but after Israel took over, it was obliged to respect the status quo and not make any changes to the status, laws and institutions in occupied East Jerusalem.
Kingdom Hearts 3 Out In 2018, Includes Toy Story And More
And since Disney owns Pixar, the teams have chose to add Pixar characters such as Woody and Buzz Lightyear to the next game. Game graphics are finally good enough to make them look as if they have been ripped straight out of the movie.
The protest in Amman followed a demonstration on Friday outside the Israeli consulate in Istanbul, in which dozens of people waved Turkish and Palestinian flags and called Israel "cursed", Channel 2 reported.
United Nations chief Antonio Guterres condemned the attack, adding: "This incident has the potential to ignite further violence".
Jews are allowed to visit, but are banned from praying there to avoid provoking tensions.
Israeli authorities say most of the Palestinians killed were carrying out knife, gun or car-ramming attacks.
Israel blames the violence on incitement by Palestinian political and religious leaders compounded on social media sites that glorify violence and encourage attacks.
In addition to the developments in Jerusalem, the papers also highlighted the Israeli army killing of a Palestinian in Deheisheh refugee camp in Bethlehem during early morning clashes following an army raid of the camp to arrest activists.
The violence had greatly subsided in recent months.
"Any Palestinian who resists with any kind of violence risks having [his] home demolished or sealed and [his] entire extended family expelled onto streets".
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