"This is the right munition to reduce these obstacles and maintain the momentum of our offensive against (the Islamic State)", Gen. John Nicholson, the commander of USA forces in Afghanistan said in statement.
There was no immediate comment from the Islamic State group or other militants regarding the USA bomb attack.
And, the most powerful non-nuclear bomb ever made comes from Russian Federation, which in 2007 announced that it developed a bomb nicknamed "FOAB" - the father of all bombs - described as delivering a blast yield four-times larger than the GBU-43, according to CNN.
Asked about Trump's "total authorization" comments, a senior administration official declined to specify whether the President indeed ordered the strike in Afghanistan.
At least 94 Islamic State militants, including four key commanders, died in Afghanistan Thursday when the United States dropped a enormous bomb on a cave complex in Nangarhar province, the provincial government said Saturday.
"Fortunately there is no report of civilians being killed in the attack", Khogyani said.
The Afghan government has confirmed it was in the loop when the "Mother of All Bombs" was dropped in Nangarhar province to target the hideouts of ISIS terrorist group. The U.S. has concentrated on fighting them while also supporting Afghan forces against the Taliban.
An attack on a tunnel complex in Afghanistan using a bomb dubbed "the mother of all bombs" has left 36 Islamic State militants dead.
Those troops are separate from a wider NATO-led effort to train, advise and assist the Afghan army and police force.
The official said Nicholson wanted to demonstrate to leaders of the Islamic State affiliate in Afghanistan the seriousness of his determination to eliminate the group as a military threat.
"As ISIS-K's losses have mounted, they are using IEDs, bunkers and tunnels to thicken their defense", Nicholson said in a statement following the strike.
Brendon McCullum scores 72 in defeat
He then hung in with Virat Kohli before launching a counter-attack when the spinners came on. Yeah Samuel Badree did remind me. "Our bowling giving too many runs".
"They killed our women, youths and elders sitting them on mines". "We have the greatest military in the world, and they've done the job, as usual".
According to CNN national security analyst Peter Bergen, "the war in Afghanistan is at its lowest point for the Afghans and their American allies since the Taliban were overthrown in the months after 9/11".
A USA official told CNN that the military estimates are that the Afghan affiliate of ISIS has about 600 to 800 fighters, primarily based in two to three districts in southern Nangarhar.
Trump called Thursday's operation a "very, very successful mission".
Afghan President Ashraf Ghani said he approved of the strike, and it was created to support Afghan and U.S. forces conducting clearance operations in the region.
"Afghan and foreign troops closely coordinated this operation and were extra cautious to avoid any civilian casualties", the office of Afghan President Ashraf Ghani's office said in a statement after the strike.
The Site Intelligence Group, which tracks extremist organisations, reported a statement from the Afghan Taliban condemning the U.S. for its "terrorist" attack.
He once said the invasion of Afghanistan was a mistake, though he later walked back that statement, saying that he "always supported" USA involvement in the country. The two militant movements are rivals of each other.
The massive bomb was dropped after fighting intensified over the past week and US-backed ground forces struggled to advance on the area.
The U.S. has more than 8,000 United States troops in Afghanistan, training local forces and conducting counterterrorism operations.
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