Kisner shot a 66, and Simpson, the former US Open champ, had a 68.
McGirt, who is fresh off his Masters debut, started his round with four birdies over his first seven holes, including back-to-back birdies on Nos.
"I feel like this golf course has always been a good set up for me", Dufner said.
With his ball in a bunker, Graham DeLaet looks over his notes for the best approach on on the 15th hole.
DeLaet had three birdies against a single bogey, as well as holing his approach from 108 yards to the ninth for eagle in a round of 67.
DeLaet entered the week in 72nd place in the FedEx Cup Standings.
"We couldn't see the bottom of the pin, but there was reaction from the crowd so we figured it was in, " DeLaet said.
"I'm looking forward to not getting up at 4:45 a.m. again like I did this morning", DeLaet said laughing.
In his first six RBC Heritage appearances, DeLaet's best finish was 14th a year ago.
DeLaet is seeking his first tour win and knows it will take a mental effort to keep him straight.
Ogilvy made a promising start with birdies at the second and fourth holes but he faltered with successive double bogeys at the 11th and 12th.
Thwarted attack rattles France days before presidential vote
Macro still leading the field with an average of 23% of the French population supporting either candidate, but with Mr. Le Pen cast the election as a decision between her "patriotism" and her opponents' "savage globalisation".
Donald has shot in the 60s in 21 of his 42 career rounds at Harbour Town.
"It was a little more stressful than I would have liked", Donald said after a second-round 67.
DeLaet was second after a 69, his third straight sub-70 round after having just five in five previous appearances here. "But the grass is really nice so you can really get it to nip and just played it perfectly". "I've had to work on clearing everything out of my mind to go play good golf".
But Scotsman Russell Knox, who missed the cut at Augusta, had four birdies in five holes in a 66 to reach six under, one ahead of England's Tyrrell Hatton.
Jason Dufner had two eagles on the way to a 6-under 65 and a one-shot lead Saturday heading into the final round of the RBC Heritage at Hilton Head Island, S.C.
CHAMPIONS: Bob Tway bogeyed two of the last three holes for 7-under 65 and the first-round lead in the Mitsubishi Electric Classic in Duluth, Ga. He finished the tournament at 1-over par 143. This is the first time the first two rounds at RBC Heritage were both under par for the field. He had five birdies and two bogeys in the second round.
The 39-year-old has finished second in the event four times in the past eight years but has yet to claim the plaid jacket and he will begin Friday's round tied for second place. He holed out for eagle from the fairway on the par-four 12th and played the opening nine in six-under 30. Miguel Angel Jimenez and Jose Maria Olazabal also shot 69.
Oahu, United States: South Korea's Kim In-Kyung vaulted into a share of the lead with a sizzling eight-under 64 in Thursday's second round of the LPGA Tour's Lotte Championship.
Gregory Havret took the outright lead at the Trophee Hassan II in Morocco as he moved to six under par after the second round.
At the top of the leaderboard an Easter bun fight was developing with nine players within two shots of the lead going into the back nine.
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