Le Pen, who also came under attack from conservative candidate Fillon, retorted: "You shouldn't pretend to be something new when you are speaking like fossils that are at least 50 years old".
"EU treaties lock us in a social and economic policy that crush the French people", said Asselineau, the leader of the nationalist Popular Republican Union.
Once the frontrunner, the conservative former prime minister's poll ratings have slumped since allegations surfaced that he paid his wife and sons hundreds of thousands of euros of public money for minimal work.
Macron, who seeks to transcend the classic left-right divide in French politics, was voted the most convincing performer in a snap poll following a March 20 televised debate involving only five candidates.
Polls suggest independent centrist Emmanuel Macron and Marine Le Pen, far-right leader of the National Front, are the leading contenders.
More than 80 percent of her voters are sure of their choice, according to polling company Ifop.
It was the first time ever that all 11 French presidential candidates have appeared together in a live debate.
United Airlines changes policy after dragging man from flight
The airline also says it will no longer ask law enforcement to remove passengers from a flight unless there's a safety issue. Last week, United voluntarily removed $1 billion of market value as a result of the incident.
Le Pen replied that other countries were already introducing protectionist measures and spoke in favor of what she called "intelligent protectionism". In the run-off, all the polls show Le Pen would lose against either of these two rivals.
Macron is expected to defeat Le Pen by a margin of 61 points to 39, should the pair proceed to the head-to-head round of voting, after the candidates are narrowed down on 23 April.
"With Fillon, the more you look, the more corruption and cheating you find".
"Those who say Marine Le Pen can't win the second round are the same as those who said Trump could never win".
The others are Jacques Cheminade, who rails against the "domination" of global finance; the New Anti-Capitalist Party's Philippe Poutou; Nathalie Arthaud of the Workers Party; Francois Asselineau, who wants to quit the euro and North Atlantic Treaty Organisation; and Jean Lassalle, a self-styled "farmer-politician" without political affiliation.
All 11 candidates for the French presidency fought for the spotlight in a marathon debate Tuesday, setting out their visions for turning around a moribund economy and redefining France's place in Europe. Pledging to shrink the size of the state and tackle the debt and deficit issues head on, we would consider him to be the true reformer out of the three main candidates.
The final result of an election that is being watched closely around the world is still seen as highly unpredictable. Not long ago Le Pen's National Front party was considered too far out of the mainstream to be taken seriously.
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