"Some players don't know what makes me trust a player but Marcus I trust", Mourinho told BT Sport.
"We created a few chances and didn't take them again - we thought it might be one of those nights", he said after a victory that came at a cost due to Marcos Rojo and Zlatan Ibrahimovic suffering injuries.
Ibrahimovic limped off in the final seconds of normal time in the Europa League game against Anderlecht after hyperextending his right knee on landing, having chested down a long ball into the area.
Then when asked about his gut feeling on the prognosis of Ibrahimovic's injury in particular, he responded: "Fairly negative".
"But mentally he is excellent", Mourinho said. "Now we need absolutely everyone", he added.
Manchester United supporters are very aware that they've got a special talent on their hands with Marcus Rashford, but the teenage striker has endured a barren spell in front of goal this season.
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Players are playing through knocks, and Mourinho also has a real problem at center back with Marcos Rojo also getting injured on Saturday to likely join fellow defenders Phil Jones and Chris Smalling on the sidelines.
The teenager has earned eight senior England caps, most recently featuring for Gareth Southgate's team in March, but the FA is reportedly keen for Rashford to collect tournament experience in Poland, something Mourinho does not agree with. "We are in trouble". We are in trouble.
After winning over Anderlecht, Manchester United will be switching their focus back to the Premier League as they are set to travel to Burnley on Sunday before heading towards Manchester City on 27 April.
"I'm happy I chose this club because I think this club is the biggest in Manchester, in England and one of the biggest in the world".
"It proved to be a tough match, a tough adversary, I'm tired, I picture the players tend to be more exhausted than me", he said.
"That is why I kept Marcus on the team the whole time - for months he was not scoring a goal, but my trust in the boy is always based on his mentality".
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